Match at Tottenham Hotspur Stadium kicks off at 4.30pm BST
10 things to look out for this weekend in the Premier League
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Tottenham Hotspur (3-5-2): Lloris; Lenglet, Sanchez, Dier; Royal, Skipp, Bentancur, Bissouma, Sessegnon; Son, Kane.Subs: Forster, Doherty, Gil, Perisic, Spence, Tanganga, Moura, Davies, White.
Newcastle United (4-2-3-1): Pope; Trippier, Botman, Schar, Burn; Joelinton, Longstaff; Willock, Guimarães, Almiron; Wilson. Subs: Karius, Lascelles, Shelvey, Lewis, Targett, Manquillo, Wood, Fraser, Murphy.